|
KMID : 1009020140120010031
|
|
Clinical Psychopharmacology and Neuroscience
2014 Volume.12 No. 1 p.31 ~ p.36
|
|
|
Effects of Brilliant Blue G on Serum Tumor Necrosis Factor-α Levels and Depression-like Behavior in Mice after Lipopolysaccharide Administration
|
|
Ma Min
Ren Qian
Zhang Ji-chun
Hashimoto Kenji
|
|
|
Abstract
|
|
|
Objective: Accumulating evidence suggests that inflammation plays a role in the pathophysiology of major depression. The adenosine triphosphate (ATP)-sensitive P2X7 receptor (P2X7R) plays a crucial role in microglial activation caused by inflammation. The dye brilliant blue G (BBG) is a P2X7R antagonist. This study examined whether BBG shows antidepressant effects in an inflammation-induced model of depression.
Methods: We examined the effects of BBG (12.5, 25, or 50 mg/kg) on serum tumor necrosis factor-α (TNF-α) levels after administering the bacterial endotoxin lipopolysaccharide (LPS; 0.5 mg/kg) and the effects of BBG (50 mg/kg) on depression-like behavior in the tail-suspension test (TST) and forced swimming test (FST).
Results: Pretreatment with BBG (12.5, 25, or 50 mg/kg) significantly blocked the increase in serum TNF-α levels after a single dose of LPS (0.5 mg/kg). Furthermore, BBG (50 mg/kg) significantly attenuated the increase in immobility time in the TST and FST after LPS (0.5 mg/kg) administration.
Conclusion: The results suggest that BBG has anti-inflammatory and antidepressant effects in mice after LPS administration. Therefore, P2X7R antagonists are potential therapeutic drugs for inflammation-related major depression.
|
|
|
KEYWORD
|
|
|
Coomassie Brilliant Blue, Cytokine, Depression, Inflammation, Purinergic P2X7 receptors, Tumor necrosis factor-alpha
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|